Early studies show the canonical function of UHRF1 as a multifunctional protein is in the recruitment of DNA methyltransferase 1 (DNMT1) to DNA loci, thereby facilitating DNA hypermethylation (15, 17), which plays important roles in cell proliferation, cell cycle progression, and tumor aggressiveness (16, 18, 19). This evidence concerns the gene DNMT1 and neoplasm.