It has also been demonstrated that FAF1 plays critical roles in defence against pathogens infection, and as such, FAF1 can protect the host form Listeria infection by positively regulating NADPH oxidase‐mediated ROS production,24 and FAF1 also plays a novel role in negatively regulating virus‐induced IFN‐β production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus.25 This evidence concerns the gene IRF3 and infection.