Similarly, we also found that PIP intervention increased ROS in tumour tissue, accompanied by the decreased expression of Bcl‐2, but the increased expression of Bax, Cyt‐c, Caspase‐3 and Caspase‐9, suggesting that PIP can also activate mitochondrial apoptosis in vivo, which was consistent with cellular findings. The gene discussed is BAX; the disease is neoplasm.