We found that TP53 and APC mutations were prone to be detected in patients with non-pCR and high pTRG grade (P = 0.11 of TP53 and P = 0.10 of APC for pCR, P = 0.04 of both TP53 and APC for TRG), whereas both of HRR and HMT showed an opposite trend (Fig 2A and 2B), particularly for HRR pathway (P = 0.002 for pTRG), suggesting that mutations in these 2 pathways may sensitize cancer cells to radiochemotherapy. Here, APC is linked to cancer.