For example, methylation CpG sites located in ACAA2, NUSAP1, OGFOD1, PSMD5, SNRNP40 and XRCC6 are simultaneously associated with five cancers including BRCA, CESC, COAD, KIRP and SARC; methylation CpG sites located in USP37 are simultaneously related to four cancers (i.e., BRCA, CESC, COAD and SARC). This evidence concerns the gene XRCC6 and cancer.