MAPT and Alzheimer disease: In a previous study PI2620 demonstrated higherbinding affinity to the core site and entry site compared to the concavesites of the AD-tau fibrils.38 Similarly,for CBD-tau, the entry site e1 showed a binding free energy of −41.5kcal/mol while site s12 at the concave region showed a stronger bindingaffinity to PI2620 than that at the core site.