MAPT and corticobasal degeneration disorder: We here present the first computational studyon the binding profiles of four tau different PET tracers, PI2620,CBD2115, PM-PBB3, and MK6240, to corticobasal degeneration (CBD) tau.The in silico results showed different preferencesfor the various binding sites on the 4R fibril, and especially anentry site, a concave site, and a core site showed high binding affinityto these tracers.