There are, however, large histopathologicaldifferences between the tauopathies such as Alzheimer’s disease(AD) (neurofibrillary tangles) and primary tauopathies, such as progressivenuclear palsy (PSP), corticobasal degeneration (CBD), chronic traumaticencephalopathy (CTE), globular glial tauopathy (GGT), argyrophilicgrain disease (AGD), and Pick’s disease (PiD).1−4 Tau aggregation has been identified as filaments, which generateabnormal tau fibrils in brain. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.