MAPT and Alzheimer disease: Recent studies indicate that the tau fibril variesin its folding pattern between different tauopathies,7 indicating that each tauopathy is characterized by a disease-specificmisfolding mode, e.g., AD-fold and CBD-fold (Figure 1).8,9 The imaging of the differenttau fibrils has become an important goal for early detection and differentialdiagnosis of various neurodegenerative diseases.8,10−12