Several modes of interaction between Akt and androgen signalling via AR have been suggested, however, predominantly in prostate cancer, including direct phosphorylation and inhibition of AR by Akt, regulation by Akt via the wnt/GSK3B/ß‐catenin pathway, crosstalk of AR and Akt involving NF‐ kB and suppression of AR by Foxo1.23, 24, 25. The gene discussed is FOXO1; the disease is Familial prostate cancer.