We have found no studies on PGRN or activin A in acute exacerbations of idiopathic pulmonary fibrosis, and this study aimed to examine the concentrations of PGRN and activin A in the serum of patients with acute exacerbations and compare them with those in stable idiopathic pulmonary fibrosis to investigate any potential pathogenetic significance. The gene discussed is GRN; the disease is pulmonary fibrosis.