Seroconverted levels of RBD-specific IgM and IgG antibodies were detected in the majority of COVID-19 respiratory samples (10/13) and patients (6/9) at 77% and 67% (Fig. 3f), suggesting prominence of RBD-specific IgM and IgG in respiratory samples during acute COVID-19. This evidence concerns the gene CD40LG and COVID-19.