Indeed, polyphenol-rich extracts from Pleurotus eryngii, green tea, and green coffee have shown promising effects in the treatment of inflammatory disease and colon cancer by suppressing p-IκB protein expression, inhibiting NF-κB and IκB mRNA expression, and arresting the cell cycle at the G2/M phase [7–10]. The gene discussed is NFKB1; the disease is colonic neoplasm.