CD11c;Ripk1kd/kd;Ripk3ΔR/ΔR;Fadd+/− mice were also significantly protected from DSS-induced colitis compared with Ripk1kd/kd;Ripk3ΔR/ ΔR;Fadd+/−mice (Fig. 6a–c). This evidence concerns the gene ITGAX and colitis.