Similarly, many other complement components (complement component C8 alpha chain, complement component C8 beta chain, complement component 4A, complement factor H, and complement C2) were also significantly decreased (fold change of MCO/1st HF < 1.0) during the MCO period (Supplemental Fig. 1A), as were those of the coagulation factors X and IX (Supplemental Fig. 2B). This evidence concerns the gene C4A and hydrops fetalis.