Cadherin 5 (CDH5), KNG1, lumican (LUM), RBP4, SERPINC1, and SERPINF1 are involved in the apoptosis of endothelial cells and related processes, and this process was predicted to be inactivated in MCO compared to that in the 1st HF (activation z-score =  − 1.985). The gene discussed is LUM; the disease is hydrops fetalis.