Preceding studies have shown that 2ccPA is much potent in inducing several biological activities compared with naturally occurring cPA, which include suppression of lysophospholipase D (lysoPLD) activity of autotaxin (ATX), tumour cell migration1,6, delay of neuronal death following transient ischemia7, neuropathic pain8, and cuprizone-induced demyelination (demonstrated in a multiple sclerosis model)9. Here, ENPP2 is linked to multiple sclerosis.