In animal models of genetically induced obesity variable alterations of Glo-1 gene and protein expression have been described depending on the experimental conditions and the examined tissue55,56, with generally a decrease in enzymatic activity that can rather be due to due to the high AGEs influx and to the exhaustion of its cofactor GSH57,58. The gene discussed is GLO1; the disease is obesity due to melanocortin 4 receptor deficiency.