The intrahepatic accumulation of MG-H1, CML, and CEL in the obese LeptrDb−/− mice were accompanied by increased expression of RAGE, activation of NFkB, and to activation of the SREBP1c lipogenic pathway, probably contributing to hepatosteatosis. This evidence concerns the gene NFKB1 and Chronic Eosinophilic Leukemia, Not Otherwise Specified.