NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Although mRNA expression of Nrf2 (Fig. 5a) was unaffected in obese RAGE+/+LeptrDb−/− and RAGE−/− LeptrDb−/− mice, nuclear protein levels of Nrf2 were increased in obese RAGE+/+LeptrDb−/− mice, suggesting enhanced transcriptional activity in obesity.