Methyl-seq data in LUAD cell lines indicated that whereas CT-GABRA3 activation was associated with DNA hypermethylation within its transcription unit (region B), it was instead associated with reduced DNA methylation levels in the neighboring regions A and C. This likely reflects the fact that activation of CT-GABRA3 occurs preferentially in tumor cells with global genome hypomethylation (Fig. 2C). Here, GABRA3 is linked to neoplasm.