MS is also associated with low-grade inflammation characterized by increased circulating levels of pro-inflammatory factors, such as interleukin (IL) -1beta, IL-8, tumor necrosis factor alpha (TNF-alpha), leptin, resistin as well as pro-fibrotic growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta)2. The gene discussed is LEP; the disease is myeloid sarcoma.