Moreover, taking into account the function of the UGT1A1 protein, one of the main proteins involved in glucuronidation of drugs and other compounds14, as well as elimination of estrogens and the consequent reduction of their circulating pool16, lower weight may be expected in women with osteoporosis as compared to their postmenopausal healthy peers. This evidence concerns the gene UGT1A1 and osteoporosis.