Conducted scientific studies analyze the influence of genetic variants of the UGT1A1, including UGT1A1*6 (211G>A, rs4148323), UGT1A1*27 (686C>A, rs35350960), UGT1A1*60 (− 3263T>A, rs4124874), and TA repeat variation of UGT1A1*28 (A(TA)7TAA, rs3064744) on the risk of developing osteoporosis or other pathological entities, e.g. Gilbert's Syndrome. The gene discussed is UGT1A1; the disease is osteoporosis.