Consistent with the reduction of β-catenin abundance in AEG-1 silencing glioma cells, a large restraint of PD-L1 expression (Supplementary Fig. S3) and an increased CXCL10 expression (Supplementary Fig. S4) were observed, implying that AEG-1 may play a potentially broader role in tumor immune evasion which worth further investigation. The gene discussed is CXCL10; the disease is central nervous system cancer.