PLN and familial dilated cardiomyopathy: A mouse model carrying the PLN R14del pathogenic variant in both alleles (PLN R14Δ/Δ) recapitulated all common features of the human phenotype observed in heterozygous carriers, yet in an accelerated fashion, with rapid development of DCM, myocardial fibrosis, and PLN protein aggregates resulting in premature death at the age of 8–9 weeks27.