PLN and familial dilated cardiomyopathy: Strikingly, magnetic resonance imaging (MRI) of the heart at 7 weeks of age revealed almost completely normal cardiac dimensions and function in PLN-ASO treated mice, whereas severe DCM was observed in vehicle-treated mice (Fig. 2e, f, LVEF 53 ± 2 vs. 27 ± 2%, P value < 0.0001, left ventricular end-diastolic volume [LVEDV] 41 ± 2 vs. 54 ± 2.0 mL, P value < 0.0001 and left ventricular end-systolic volume [LVESV] 20 ± 1 vs. 39 ± 2 mL, P value < 0.0001).