PLN and cardiomyopathy: Another typical hallmark of PLN R14del cardiomyopathy in humans is a low voltage ECG, which was also observed in PLN R14Δ/Δ mice (Fig. 2h, i, expressed by low R-amplitude), and was partially restored by PLN-ASO treatment (0.84 ± 0.05 vs. 0.55 ± 0.05 mV, P value < 0.0001).