In line with the cell-growth data, knockdown of DHODH expression markedly inhibited the anchorage-independent growth of BE(2)-C cells in soft agar (Fig. 3F, G), slowed the growth of BE(2)-C xenografts in immunodeficient mice (Fig. 3H and Fig. S3G), and prolonged the survival of tumor-bearing mice (Fig. 3I). This evidence concerns the gene DHODH and neoplasm.