Moreover, treatment with BRQ and GSK983 had no effect on the expression of DHODH or other enzymes of the pyrimidine-synthesis pathway in the absence or presence of MYCN overexpression (Fig. S4B), providing further evidence that these inhibitors repressed neuroblastoma cell proliferation by inhibiting DHOHD enzyme activity but not by regulating its expression. Here, DHODH is linked to neuroblastoma.