TP53 and neoplasm: In addition to activating p53; RPL5, RPL11 and RPS14 have been shown to bind to the p53 homolog p73 to prevent Mdm2 from binding to p73 at target gene promoters, such as those of p21 and Puma, leading to p73 activation and p73-dependent apoptosis.128 Intriguingly, simultaneous knockdown of p73 and either RPL5 or RPL11 was required to rescue 5-FU-induced apoptosis of p53-null tumor cells,128 supporting the essential role of RPL5 and RPL11 in p73-mediated apoptosis.