Using genetically engineered models of Eμ-Myc lymphoma, Bywater et al. demonstrated that CX-5461 induces nucleolar disruption, resulting in the binding of unassembled RPL5 and RPL11 to Mdm2 and subsequently rapidly activating p53-mediated cell cycle arrest and apoptosis39 (Fig. 4). Here, MYC is linked to lymphoma.