GATA1 and Diamond-Blackfan anemia: Genome-wide translational profiling of cellular models of ribosomopathies has revealed that translation of subsets of mRNAs, particularly mRNAs encoding proteins involved in cell fate decisions, are specifically impaired under the limited availability of functional ribosomes.23 Particularly, the specific reduction in translation of GATA1, a master regulator of hematopoiesis, contributes to bone marrow erythroid hypoplasia in DBA patients.143,181,182 Selective translation defects have also been described in some mRNAs containing an internal ribosome entry site (IRES).