Reduced translation of the key erythroid transcription factor GATA1,143 increased degradation of the GATA1 chaperone HSP70,144 or mutation in the RPS26 chaperone protein TSR2,145 impairs erythroid lineage commitment, resulting in specific defects in erythropoiesis in DBA. The gene discussed is GATA1; the disease is Diamond-Blackfan anemia.