PSPH and acute lymphoblastic leukemia: The upregulation of phosphoserine phosphatase (PSPH) transcription and translation detected in the lymphoid cells with the RPL10-R98S mutation was thought to contribute to ribosomal mutation-driven serine/glycine synthesis in T-ALL.230 In addition, altered proteasome activity in RP mutant cells induces proteomic changes and promotes pro-oncogenic pathway activation.