In addition, we found that the interaction between VAV2 and Ku70/Ku80 in ESCC cells could be altered by forced VAV2 expression change: silencing VAV2 expression by siRNA substantially reduced the interaction (Fig. 4h), but overexpression of VAV2 substantially enhanced the interaction (Fig. 4i). This evidence concerns the gene VAV2 and esophageal squamous cell carcinoma.