CCNB1 and cancer: Using a bioinformatics database (TargetScan), we found that cyclin B1, a vital pusher of radioresistance in several types of cancer by regulating the cell cycle [37–39], was the potential target of miR-139-5p and the potential binding sites between CCNB1 (the encoding gene of cyclin B1) and miR-139-5p are shown in Fig. 4E.