Upregulated CXCL1 promoted renal ischemia-reperfusion injury, which can cause intrinsic acute renal failure [15] Considering all the above findings, we hypothesize in this study that OGT may affect hypercalcemia-induced nerve injury in renal failure by regulating the EZH2/KLF2/CXCL1 axis. Here, CXCL1 is linked to hypercalcemia disease.