Besides the use of human brain material, three main “classes” of models have emerged from these translational attempts: (1) pharmacological manipulation of main neurotransmitter systems, (2) genetic manipulations of human susceptibility genes (e.g., Disrupted-in-Schizophrenia 1 (DISC1) or neuregulin mutations), and (3) developmental manipulations (e.g., neuronal activity blockade, infection, trauma) in which synaptic and network assembly are corrupted during a critical neonatal period [32–36]. Here, DISC1 is linked to infection.