Whereas STAG1 was the only negative genetic interaction shared in all three cell backgrounds, several other gene candidates were found in two out of three lines and we wondered if we could learn more about STAG2 function and genetic interaction context-dependency by further characterizing one of these, namely, the STAG2/IREB2 interaction observed in the cancer-derived HAP1 leukemia and H4 glioblastoma cell lines. The gene discussed is STAG2; the disease is glioblastoma.