The efficacy of early reperfusion therapy for acute ischemic stroke with tissue plasminogen activator (t-PA; The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group, 1995; Hacke et al., 2008) and mechanical thrombectomy with a stent retriever (Goyal et al., 2016) has been established by randomized controlled trials. This evidence concerns the gene PLAT and Stroke.