For instance, circARFGEF2 was found to be overexpressed in portal vein tumor thrombus (PVTT) and HCC tissues and to promote the EMT process via a miR-143-3p/FOSL2 axis and PCBP1/CD44v6 axis (FOSL2 is an EMT-related stimulator, and CD44v6 is an EMT-activating gene), leading to a remarkable acceleration in intrahepatic and pulmonary metastasis [46]. Here, FOSL2 is linked to hepatocellular carcinoma.