For example, circMAT2B is involved in HCC glucose metabolism reprogramming and malignancy, and a previous study demonstrated that under hypoxic conditions, circMAT2B can induce HCC progression by enhancing glycolysis via activation of the circMAT2B/miR-338-3p/PKM2 axis, which may provide a therapeutic target for HCC [44]. This evidence concerns the gene PKM and hepatocellular carcinoma.