CSF1 and hepatocellular carcinoma: Another study demonstrated that circASAP1 was overexpressed in high metastatic potential HCC and metastatic HCC and functioned as a ceRNA for miR-326 and miR-532-5p to regulate the expression of their direct targets MAPK1 and CSF-1, thereby promoting HCC cell proliferation and invasion and mediating tumor-associated macrophage infiltration [37].