Considering that TAM/CXCL1 activity within the TME represents a reliable target for TCM to prevent breast cancer immune escape and metastasis [17, 18], it is important to analyze whether ADQ also suppresses breast cancer metastasis by remodeling the immunosuppressive TME via modulating TAM/CXCL1 activity. The gene discussed is CXCL1; the disease is breast carcinoma.