MTOR and pancreatic neoplasm: In pre-clinical studies of pancreatic cancer, many mTOR inhibitors have shown a variety of inhibitory effects on pancreatic cancer cells and inhibit epithelial to mesenchymal transition, including the first generation of mTOR inhibitors rapamycin, the second generation of mTOR inhibitors such as KU63794 and PP242, and the new mTOR inhibitor INK-128 dual mTOR inhibition [58, 59].