TP53 and non-small cell lung carcinoma: We found that compared with NSCLC cells with UBE2T depletion, the addition of pifithrin-a (PFT-a) to UBE2T deficient cells restored autophagy, as indicated by the increased LC3II and decreased p62 in cells manipulated by genetically silencing UBE2T and p53 inhibitor (Fig. 3D, F).