E2F1 and posterior cortical atrophy: Consistently, avasimibe-induced EMT-related protein alterations were rescued by E2F-1 knockdown, and the expression of the EMT-related proteins Vimentin, N-cadherin, and Snail was increased and that of E-cadherin was decreased in the PCa cells with E2F-1 knockdown and avasimibe treatment compared with the cells treated with avasimibe alone (Fig. 5h).