For example, hsa-mir-92 directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues and was recently proposed as a key oncogenic component of miR-17–92 cluster through targeting and down-regulating the proapoptotic protein Bim in CN [48]. This evidence concerns the gene BCL2L11 and malignant colon neoplasm.