CHEK2 and rectal cancer: However, multiple primary cancers were diagnosed in three of nine carriers of this mutation (33.3%)(rectal cancer, myeloid leukemia and skin squamous cell carcinoma) In a previous study we reported a correlation between the c.470C > T mutation in the CHEK2 gene and multi-organ cancer susceptibility (breast, colon, kidney, prostate and thyroid cancer) with odds ratios ranging between 1.5 and 2.0 [65].