Although the outcomes of the studies vary, older age, male sex, obesity, hypertension, type 2 diabetes mellitus, active malignancy, coronary artery disease, a low PaO2 / FiO2 ratio on admission, the need for invasive mechanical ventilation (IMV), high D-dimer and C-reactive protein (CRP) levels were defined as risk factors for mortality in different patient cohorts [3–8]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.