Further analysis from brain regions of frontal and temporal lobes demonstrated age (OR = 1.067, 95%CI 1.050–1.085) and IGF2BP2 (OR = 2.633, 95%CI 1.248–5.552) were promotive to AD, while METTL16 and LRPPRC were protective to the prevalence. This evidence concerns the gene IGF2BP2 and Alzheimer disease.