METTL16 and Alzheimer disease: Except for YTHDC2 was downregulated in the ɛ4+ group, the other four DEGs (METTL3, METTL16, RBMX, and LRPPRC) were upregulated epigenetic alterations of RNA methylation might be related to APOE ɛ4 dysfunction in AD (Figure 7A–7E).