Except for YTHDC2 was downregulated in the ɛ4+ group, the other four DEGs (METTL3, METTL16, RBMX, and LRPPRC) were upregulated epigenetic alterations of RNA methylation might be related to APOE ɛ4 dysfunction in AD (Figure 7A–7E). The gene discussed is METTL3; the disease is Alzheimer disease.