In contrast, the HPSE expression was decreased in colon adenocarcinoma (COAD), head and neck cancers (HNSC), kidney renal clear cell carcinoma (KIRC), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), and uterine corpus endometrial carcinoma (UCEC). Here, HPSE is linked to colon adenocarcinoma.