In breast cancer, the HPSE expression had no correlation with Th2 cells, a weak positive correlation with M1 macrophages, NK cells, and Th17 cells, a medium positive correlation with TAM, exhausted T cells, Tfh cells, Th1 cells, and Treg cells, and a strong positive correlation with M2 macrophages and monocytes. The gene discussed is HPSE; the disease is breast cancer.