Furthermore, we found that METTL3, METTL14, METTL16, WTAP, VIRMA, RBM15, RBM15B, YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, HNRNPC, FMR1, LRPPRC, HNRNPA2B1, RBMX, FTO, and ALKBH5 were significantly upregulated in HCC tissues compared to their expression in normal tissues, whereas IGFBP1 and IGFBP3 were significantly downregulated (p < 0.05; Figure 1D). The gene discussed is IGFBP1; the disease is hepatocellular carcinoma.