Moreover, we analyzed tumor somatic mutations in the high and low m6Sig score subgroups separately, and found a higher somatic mutation rate in the low-m6A score group for TP53 (55% vs. 19%) and a lower somatic mutation rate for CTNNB1 (15% vs. 27%) (Figure 4D, 4E). Here, CTNNB1 is linked to neoplasm.