Further measurement of the expression levels of HMGB2 protein and mRNAs in the tumor tissue of nude mice displayed that the expression levels of HMGB2 protein and mRNAs in the tumor of nude mice injected with miR-23b-3p-mimcis was significantly inhibited, while the expression levels of HMGB2 protein and mRNAs in the tumor of nude mice co-transfected with sh-KTN1-AS1+miR-23b-3p-mimics was reversed. The gene discussed is HMGB2; the disease is neoplasm.