Moreover, We found for the first time that increasing the expression of KTN1-AS1 could noticeably promote the invasion and proliferation of PC cells and inhibit apoptosis, while on the contrary, inhibited KTN1-AS1 presented a conversed effect, which suggested that KTN1-AS1 played a role in promoting oncogenes in PC. This evidence concerns the gene KTN1 and pachyonychia congenita.