MYD88 and chronic recurrent multifocal osteomyelitis: These data suggest that priming of leukocytes through TLR/MyD88 or TLR/TRIF signaling does not play any major role in CMO development since Pstpip2cmo hematopoietic cells without functional MyD88 or TRIF adaptors were fully capable of driving the autoinflammation.