In conclusion, we found a high burden of bone and gonadal disease in HIV-infected men under cART, and we showed that, in the multifactorial set of elements involved in the pathogenesis of bone fragility, besides low testosterone levels, FSH might have a negative impact on hip BMD, and, more importantly, higher SHBG values might be predictive for VFs occurrence in this population. This evidence concerns the gene SHBG and gonadal disorder.