SHBG and HIV infectious disease: The comparison of patients with and without VFs showed that fractured patients were older (median age 55 vs 52 years, p = 0.048), more frequently drug users (p = 0.047), had longer HIV infection duration and cART exposure (p = 0.015 and p = 0.002, respectively), and were more frequently hypogonadal (p = 0.044) and with higher SHBG values (p = 0.010).