Compared to HDL from AF patients before ablation, HDL from AF patients at FU significantly decreased the gene-expression of ICAM1 (69.9%, 50.1–126.0, n = 18 vs. 37.5%, 25.3–49.1, n = 14, p = 0.004), SELE (55.8%, 22.0–86.1, n = 20 vs. 18.3%, 15.2–34.2, n = 14, p = 0.012) and SELP (85.1%, 50.5–135.6, n = 22 vs. 10.0%, 7.2–14.8, n = 14, p < 0.001). This evidence concerns the gene SELP and atrial fibrillation.