STAT1 and acute lymphoblastic leukemia: Moreover, at day 17, B‐ALL cells from treated animals showed reduced expression of the IFN‐γ receptors and signal transducers (Ifngr1, Ifngr2, and Jak1), accompanied by reduced intracellular signaling via Stat1 and Irf1 (Fig 5I), possibly indicating the development of a resistance mechanism to IFN‐γ (Arenas et al, 2018).