Based on the MHC II molecule expression module score, we divided B‐ALL cells from IFN‐γ d12 into an MHC II high subpopulation, displaying enrichment for IFN‐responsive gene modules, and an MHC II low subpopulation, with higher expression of proliferative and oxidative phosphorylation pathways (Fig 5G and H). Here, IFNG is linked to acute lymphoblastic leukemia.