IL10 and precursor B-cell acute lymphoblastic leukemia: Our B‐ALL model rapidly induces an immunosuppressive microenvironment, including downregulation of MHC II genes, up‐regulation of IL‐10 (Escobar et al, 2018), and accumulation of non‐classical monocytes, which have recently been shown to play a pivotal role in B‐ALL progression (Witkowski et al, 2020).