Moreover, at day 17, B‐ALL cells from treated animals showed reduced expression of the IFN‐γ receptors and signal transducers (Ifngr1, Ifngr2, and Jak1), accompanied by reduced intracellular signaling via Stat1 and Irf1 (Fig 5I), possibly indicating the development of a resistance mechanism to IFN‐γ (Arenas et al, 2018). The gene discussed is IRF1; the disease is acute lymphoblastic leukemia.