Next, we undertook an unbiased transcriptional characterization of the B‐ALL immune microenvironment performing 10× single‐cell RNA sequencing (scRNAseq) on total BM cells from mice treated or not with IFN‐γ gene therapy (controls indicated as blue dots, IFN‐γ as yellow dots in Fig 1B). Here, IFNG is linked to acute lymphoblastic leukemia.