Although xylo‐cyclophellitol 1 does not outperform[35, 44] in terms of GBA selectivity the previously described C8 alkyl‐diphenyl or alkyl‐adamantyl cyclophellitols, it remains a promising compound for generating improved chemical knockout of GBA‐deficient cell and animal models in the context of Gaucher disease and Parkinson's disease. This evidence concerns the gene GBA1 and Parkinson disease.