Although xylo‐cyclophellitol 1 does not outperform[35, 44] in terms of GBA selectivity the previously described C8 alkyl‐diphenyl or alkyl‐adamantyl cyclophellitols, it remains a promising compound for generating improved chemical knockout of GBA‐deficient cell and animal models in the context of Gaucher disease and Parkinson's disease. Here, GBA1 is linked to Gaucher disease.