TP53 and neoplasm: It has been well‐established that perturbation of any single step of ribosome biogenesis by, for example, Actinomycin D41, 42 or CX‐5461,26, 43 triggers a drastic cytotoxic effect, namely ribosomal stress or nucleolar stress, unleashing tumor suppressive signals involving activation of the tumor suppressors p53 and TAp73,44, 45, 46 and inhibition of the c‐Myc pathway.25, 47, 48