Activated CAFs could significantly induce the invasion of ESCC cells, whereas the invasion of KYSE30 and KYSE410 cells was largely inhibited when IL‐6, IL‐7, IL‐8, CCL5, or TGF‐β1 Ab (10 μg/ml) was added to the coculture transwell system (Figure 8C). This evidence concerns the gene IL6 and esophageal squamous cell carcinoma.