As the specific mechanisms that affect the predominantly osteoblastic phenotype remain to be excavated, the current study sought to dissect out the effect of exosomes‐encapsulated NEAT1 from PCa cells, miR‐205‐5p, RUNX2, and SFPQ/PTBP2 in the osteogenic differentiation of hBMSCs and their underlying mechanisms. The gene discussed is SFPQ; the disease is posterior cortical atrophy.