Our obtained findings suggested that NEAT1 shuttled by PCa‐derived exosomes could be transferred into hBMSCs, where NEAT1 exerted inductive effects on osteogenic differentiation of hBMSCs through the upregulation of RUNX2 by competitively binding to miR‐205‐5p and regulating SFPQ/PTBP2 both in vitro and in vivo. Here, SFPQ is linked to posterior cortical atrophy.