Long‐term high‐fat diet (HFD) and palmitic acid (PA) significantly upregulate the expression of pyroptosis‐related molecules including NLRP3, GSDMD, GSDMD‐NT, caspase‐1, cleaved caspase‐1 (p20), IL‐1β, and IL‐18 in NAFLD.207. The gene discussed is GSDMD; the disease is metabolic dysfunction-associated steatotic liver disease.