GSDMD and cancer: GSDMD is expressed in various cells, including the gastrointestinal epithelium, placenta, and immune cells, especially macrophages and dendritic cells (DCs), as well as cancers, such as esophageal and gastric cancer, melanoma, pancreatic cancer, prostate cancer, salivary gland tumor, and Jurkat T, and Ramos B cancer cell lines.24, 124, 167, 168