In addition, in KRAS‐, EGFR‐, or ALK‐driven lung cancer, upon treatment of diverse small‐molecule inhibitors, robust pyroptotic cell death, associated with GSDME cleavage, and the mitochondrial intrinsic apoptotic pathway are elicited and spread in lung cancer cells uniformly, making concession under genotype‐specific regimens.264. The gene discussed is ALK; the disease is lung carcinoma.