TNF and cancer: However, given that (1) caspase‐8 involves both the pyroptosis, necroptosis and apoptosis pathways273, 274; (2) activation of the NLRP3 inflammasome can trigger both pyroptosis and necroptosis273; (3) GSDME‐mediated pore formation on the mitochondrial membrane is favorable for the release of cytochrome c and activation of apoptosome, augmenting apoptosis,97 it has been reported that pyroptosis induced by TNF‐α+CHX and navitoclax in cancer cells could function through the BAK/BAX‐caspase‐3‐GSDME signaling pathway.178