In the case of the most studied NLRP3 inflammasome, which is a critical sensor of nutrient overload, this can be activated by various metabolic danger signals, such as uric acid crystals in gout,189, 190, 191 cholesterol crystals and oxidized low‐density lipoprotein (ox‐LDL) in atherogenesis,192, 193, 194, 195 and glucose, fatty acids and islet amyloid polypeptide in T2D.196, 197, 198, 199. Here, NLRP3 is linked to gout.