On the other hand, given that immunotherapeutic strategies often aim to improve T cell responses to cancer, the overexpression of GSDME in cancer cells significantly increases the number and function of infiltrating NK cells and antigen‐specific CD8+ T lymphocytes inside tumors, as well as the expression of effective molecules including GZMB, perforin, IFN‐γ, and TNF‐α in TILs, together with the phagocytosis of tumor‐associated macrophages (TAMs).259, 260. The gene discussed is CD8A; the disease is cancer.