PRF1 and cancer: On the other hand, given that immunotherapeutic strategies often aim to improve T cell responses to cancer, the overexpression of GSDME in cancer cells significantly increases the number and function of infiltrating NK cells and antigen‐specific CD8+ T lymphocytes inside tumors, as well as the expression of effective molecules including GZMB, perforin, IFN‐γ, and TNF‐α in TILs, together with the phagocytosis of tumor‐associated macrophages (TAMs).259, 260