Given that IRF2 is reported as a transcription factor which regulates IFN and IFN‐inducible genes, and the down‐regulation of IRF2 in CRC cells is associated with immune suppression and immunotherapy resistance,170 the IRF2‐GSDMD regulatory axis may link GSDMD to immune activity in the tumor microenvironment (TME). This evidence concerns the gene IRF2 and colorectal carcinoma.