EZR and rheumatoid arthritis: In addition, immunohistochemical staining demonstrated that Ezrin protein expression in the vascular endothelial cells of synovial tissues from patients with RA is increased compared to the control group (75.2 ± 12.44 cells/mm3 vs. 308.8 ± 32.15 cells/mm3, p <0.01) (Figure 1D).