CGAS and Down syndrome: A number of neurodegenerative disorders, including Alzheimer's, Parkinson's disease, Werner's and Down's syndrome, constitute a collection of conditions that are associated with aberrantly elevated micronuclei frequencies (Migliore et al., 2011), but the potential neuropathogenic contribution of cGAS‐STING activation consequent to increased cytosolic DNA remains to be investigated in these conditions.